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| Id: | 25871
| | Autor: | Hadler, W. A; Ziti, L. M. | | Título: | Efeito da vacinação pelo BCG sôbre a evolução da lepra murina; observação em ratos inoculados, por via peritoneal, com pequena dose de M. lepraemurium / Effect of BCG vaccination on the evolution of murine leprosy; observation in mice inoculated by peritoneal route, with a small dose of M. lepraemurium
| | Fonte: | Rev. bras. Leprol;22(2):124-134, jun. 1954. ^bilus, ^bgraf.
| | Resumo: | The peritoneal inoculation of M. lepraemurium in the rat produces generalized lesions and a disease which shows uniforms evolution. The evolutive speed depends on the weight of inoculated bacilli. The incoculations of nearly o.03 mg of M. lepraemurium provokes only histological lesions, which progress very slowly. This slow evolution permits the observation of the influence of previous mycobacterial vaccination upon the progress and the influence of the citology of the lesions, allowing the study of the acquired resistance. Fifty young rats were divided in 4 lots: 1) 13 rats vaccinated with 25 mg of BCG by oral route; 2) 12 rats vaccinated with 5 mg of BCG, by oral route; 3) 12 rats vaccinated with 5 mg of BCG, by intramuscular route; 4) 13 non vaccinated rats (controls). All animals were inoculated 90 days after vaccination with a suspension containing approximately 0.03 mg of M. lepraemurium (by peritoneal route) and observed 450 days. The gain of weight and the histological picture observed in vaccinated and control animals are identicals; the disease shows the same evolution. The BCG vaccination does not suscitate, in the rat, acquired resistance against M. lepraemurium demonstrable by histological methods. The lesions in the vaccinated and control groups reach the same intensity in the lymph nodes, liver and apleen, and show the same slow evolution. In the animals of both groups the lesions remain almost stationary (during the all observed time), or grow slowly and progressively, or more rarely undergo involution (without complete disappearing). The histological method also shows that macrophages of the normal rat have no ability to destroy the M. lepraemurium, M. leprae and M. tuberculosis; the BCG vaccination does not induce at the macrophages the aptitude to lyse these acid-fast bacilli. On the other hand, the macrophages of normal guinea pigs have the ability to lyse these mycobacteria; the BCG vaccination provokes in the guinea pigs this physiologic...(AU)^ien.
| | Descritores: | Mycobacterium lepraemurium/genet
Mycobacterium lepraemurium/fisiol
Mycobacterium lepraemurium/patogen
Mycobacterium bovis/patogen
Hanseníase/imunol
Hanseníase/fisiopatol
| | Limites: | Animais
| | Meio Eletrônico: | http://hansen.bvs.ilsl.br/textoc/revistas/brasleprol/1954/PDF/v22n2/v22n2a02.pdf - pt.
| | Localização: | BR191.1 |
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